Take the Airline exit, go south on Airline, and turn right on E. Whitney. It's the first street south of the traffic light.
Traveling north on I-45 from downtown Houston or HOU
Go under the I-610 North Loop and take the first exit (Crosstimbers), turn left under the freeway, turn right on Airline and then left on E. Whitney.
Coming in on Hwy 290 from Austin or College Station
You may take the exit for Pinemont/43rd Street, turn left on 43rd, and travel about 5.7 miles to Oxford Street (just before the Family Dollar). Turn left on Oxford, turn right on E. Whitney.
If you prefer to stay on the freeway longer, you can continue south on 290 and exit to I-610 (the North Loop) heading east, and then follow the directions below. Depending on the time of day and traffic conditions, the drive through the neighborhoods may take about the same time and be less aggravating.
Traveling either direction on the North Loop (I-610)
You can take either the N. Main or Airline exit and go north to E. Whitney. North Main ends at E. Whitney; turn right. From Airline, turn left onto E. Whitney.
Yes, Houston has two major airports. Hobby (HOU) is south of downtown and is used primarily by Southwest. Bush (IAH) is north and is used by all other airlines.
The airports are nearly equidistant from the Knights of Columbus Hall, with Hobby being about one mile closer using the most direct route. However, it often takes a bit longer to get to the hall from Hobby because you'll have to go through or circumnavigate the downtown area, where there can be a fair amount of traffic congestion.